TREATMENT BASIS AND PATHOGENETIC BASIS OF AXIAL SPONDLITIS
Abstract
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases of the spine, joints and entheses, characterized by common clinical, radiological and genetic features. The aim of this work was to analyze modern ideas about the etiology and pathogenesis of axial spondyloarthritis (axSpA) and pathogenetically based methods for improving their treatment. The presented information is necessarily based on information from many scientific journals. The information mainly included full-text articles in Uzbek, Russian and English. The following words were mainly used for the search. Axial spondyloarthritis, ankylosing spondylitis, axial spondyloarthritis, peripheral spondyloarthritis, genetic drug periparts, medical biological treatment, biological agents, AS pathogenesis, AS treatment, AS drug treatment, non-drug treatment methods and their Russian, Uzbek and English equivalents. The authors presented an analysis of the current treatment options for AS, the advantages and disadvantages of the current treatments, and their views on how to optimize them. Promising approaches for pathogenetic treatment of AS, including the elimination of autoreactive TRBV9+ T lymphocytes, their potential role in the treatment of the disease, their expected advantages and disadvantages, and possible future treatment options were discussed. The final section of the article was to present the authors' views on potential pathogenetic treatment options for AS.
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