SYNTHESIS OF NEW AMIDES OF THIAZOLIDINE AND STUDYING THEIR BIOLOGICAL EFFECTIVENESS AGAINST CERVICAL CANCER AND BREAST CANCER IN HUMANS

Abstract

The study included the first reaction of substituted benzaldehyde compounds with cysteine to prepare compound (R). The compound (R) was then reacted with acetic anhydride to prepare the compound (RA) to protect the amine group, which was subsequently reacted with the aromatic amine phenyl hydrazine using the coupling reagents dicyclocardiimide and hydroxybenzotriazole in a solvent containing dichloromethane. This process made it possible to obtain the amide compounds. All synthesized compounds were characterized using Mass-EI NMR { 1H, 13C} and FT-IR spectra. Two different cancer cell lines were used to test the effectiveness of the compounds that were synthesized. Human cervical cancer cells and breast cancer cells. Synthetic compounds have shown biological activity against cancer cells. Due to the presence of chiral atoms, substituted thiazolidinedione derivatives have two types of diastereomers that are difficult to separate: cis-(2R,4R) and trans- (28.2R) where the percentage of isomers cis/trans depends on the type of solvent used.