PREPARATION OF HETEROGENEOUS CONGENITAL COMPOUNDS
Keywords:
Heterocyclic compound, Biological activityAbstract
The study included the preparation of heterocyclic compounds, as different types of new heterocyclic compounds were prepared, where four types of chalcones (H1, H2, H4, H6) were reacted with three different types of hydrazines (80% Hydazinehydrate and 2,4 dinitro phenyl hydrazine and (thiosemicarbazide dissolved in ethanol) in the presence of three drops of sulfuric acid H2SO4 as a catalyst from 6 hours to 24 hours, and some cases do not need a catalyst, compounds (1N,2N,4N,6N,1S,6H) were prepared, where this was diagnosed Compounds by infrared FT-IR, proton nuclear magnetic resonance spectra (HNMR) and electrospray ionization mass spectrometry (ESI), as the validity of these structures was confirmed for heterocyclic compounds. The biological activity of the prepared compounds was studied for two types of pathogenic bacteria for humans, which are fecal coliform bacteria. Gram-negative Escherichia coli, and Gram-positive bacteria, Staphylococcus aureus, that cause skin infections. . It gave the highest efficacy compound 6H against both types of pathological bacteria under test, followed by compound 2N, then compound 6N, and compound 4N, after that, the biological activity of compound 4N was studied, and its biological activity was studied as an inhibitor of cholinesterase in blood serum
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