INDIRECT ANALYSIS OF THE RESULTS OF CONSERVATIVE AND SURGICAL METHODS OF TREATMENT OF NON-SPECIFIC ULCERATIVE COLITIS

Abstract

Non-specific ulcerative colitis (UC) is a chronic recurrent disease in which the inflammation is diffuse and localized superficially, specifically affects the mucous membranes of the rectum and colon, is an autoimmune disease and is often accompanied by the development of life-threatening complications [12]. The prevalence of NAC in industrially developed countries has become almost epidemic in recent decades [5; 13]. Ulcerative colitis is reported worldwide, but the highest incidence is in North America, Northern Europe, and Australia. YAK is less common in Asia, South America and Japan. Among patients with ulcerative colitis, women are 30% more likely than men. [4]. Conservative therapy for NAC has not yet had an etiological character, so its possibilities are limited [7]. Based on this, the main method of treatment of NAC is surgical. Surgical interventions in NAC are necessary for 10-20 % of patients. In the course of life, from 10 to 30 % of patients with UC are operated on, of which 65-70 % - due to the ineffectiveness of conservative therapy, 20-25 % - due to complications and 10-14 % - due to advanced colorectal cancer [8]. Uncontrolled by, the inflammatory process leads to the progression of systemic toxic reactions and the development of intestinal complications of the disease: bleeding – in 1.5-4 %, toxic dilatation and perforation – in 5-6 % [6]. In the initial stages of the disease, treatment is directed to drug therapy [11].Traditional basic therapy does not allow us to fully solve the tasks set[3]. Over the past decades, the view of providing surgical care to patients with ulcerative colitis has undergone a significant evolutionary development [1; 9]. To date, the frequency of early postoperative complications in planned interventions reaches 10%, in emergency cases-up to 60%, and the mortality rate ranges from 12 to 50% [2; 10]. The unresolved nature of these issues makes the problem of non-specific ulcerative colitis relevant to its treatment.