CLINICAL AND LABORATORY CHARACTERISTICS OF PNEUMOCOCCAL MENINGITIS IN ADULTS

Abstract

The analysis of the incidence of pneumococcal meningitis was carried out in the period from 2008-2018 according to the data of a retrospective analysis of the case histories of patients who were hospitalized in the regional clinical infectious diseases hospital in the city of Samarkand.The clinical picture of the examined patients with pneumococcal meningitis was characterized by an acute onset of the disease with a pronounced intoxication syndrome. Among the examined patients with pneumococcal meningitis by the bacteriological method, S. Pneumonia was confirmed in 12.4% of the total. In pneumococcal meningitis, such residual effects are often detected in adults: sensorineural hearing loss (16.4%), hypertensive syndrome (38%), cerebrovascular accident (45.6%). At the present stage, the diagnosis of pneumococcal meningitis requires the use of a complex of methods, including not only microscopic, bacteriological and serological examination (latex agglutination), but also PCR detection of pathogenic microorganisms in the cerebrospinal fluid, the diagnostic value of which is more than 80%. Neuroprotective therapy (osmotic diuretics, anticonvulsants, nootropics) can improve the outcome of pneumococcal meningitis and appears to be a promising treatment option. Adults, existing risk factors for the development of pneumococcal meningitis (elderly and immunocompromised persons) are shown specific prophylaxis of pneumococcal infection (vaccination).